SINCE Wwii, medical science has progressed with a stage where competitive medications are available to treat exactly the same ailment in numerous people. This isn’t just about brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall glance at the various factors that decide picking a a specific drug.
Safety: The next sub-criteria has to be considered under the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective can be a particular drug even though they have certain side-effects as long as the acuteness in the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but feature the potential side-effect of addiction.
* Long-term safety: drug could be safe in short-term treatment, so how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and a lot of chemicals reply to create a different chemical, that have an effect that will harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of one another, have certain effects using one or higher body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by for the metabolism. This leads to a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually produce the same relation to exactly the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both the drugs are more serious.
Tolerability: A medicine could be effective however, not tolerable by all patients. Example: Allergies to particular drugs in certain people. Short-term and long-term tolerability need to be considered. Efficacy: A medicine just isn’t equally great at all patients. By way of example, some patients with depression or panic disorders experience relief from escitalopram, but there are many that don’t, who therefore need to be prescribed another anti-depressant. The pace of start of therapeutic action is a key to be considered too.
Cost: Cost does not mean the expense of acquiring a certain medicine alone. It should also cover the expense of management of a complication that will arise by using another drug. Example: Within a person who insists on taking alcohol but should be treated for depression is normally administered an SSRI drug because they drugs don’t potentiate the consequences of alcohol, whereas another number of anti-depressants (including tricyclics) may cause a fresh symptom in such patients, which will require a different and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram as opposed to a cheaper tricyclic such patients.
Simple treatment: The easiest mode of administration is preferred. If there is an alternative between an injection and oral administration, the latter is preferred if your efficacy of both the modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are an important factor to make a decision simplicity of treatment.
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