SINCE Wwii, medical science has progressed with a stage where competitive medications are available to treat the same ailment in numerous people. This isn’t nearly brands (that is a trade issue) but generic drugs (that is a scientific issue). Within this report, we shall consider the various factors that decide your selection of a certain drug.
Safety: These sub-criteria must be considered under the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is a particular drug even though it’s got certain side-effects as long as the acuteness in the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but include the possible side-effect of addiction.
* Long-term safety: medication could possibly be safe in short-term treatment, but how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and several chemicals react to make a different chemical, that have an effect which could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of each other, have certain effects on a single or higher body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon for the metabolism. This causes more the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually create the same influence on the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the two drugs are more intense.
Tolerability: A medication could possibly be effective however, not tolerable by all patients. Example: Allergies to certain drugs in most people. Short-term and long-term tolerability should be considered. Efficacy: A medication isn’t equally efficient at all patients. For instance, some patients with depression or panic disorders experience respite from escitalopram, but there are several that do not, who therefore should be prescribed a different anti-depressant. The interest rate of beginning of therapeutic action is an important step to be regarded too.
Cost: Cost does not mean the expense of buying a certain medicine alone. It should also cover the expense of treating a complication which could arise while using a different drug. Example: Inside a individual that insists on taking alcohol and yet needs to be treated for depression is generally administered an SSRI drug as these drugs don’t potentiate the results of alcohol, whereas another number of anti-depressants (like tricyclics) can cause a new problem in such patients, which could require a various and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram as opposed to a cheaper tricyclic in such patients.
Simple treatment: Most effective mode of administration is preferred. When there is a selection between a shot and oral administration, rogues is preferred in the event the efficacy of the two modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are an important factor to determine simple treatment.
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