SINCE World war 2, medical science has progressed into a stage where competitive medications are available to treat exactly the same ailment in numerous people. This is not just about brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall look at the various factors that decide your selection of a particular drug.
Safety: The subsequent sub-criteria should be considered beneath the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective can be a particular drug regardless of whether it has certain side-effects provided that the acuteness from the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but include the possibility side-effect of addiction.
* Long-term safety: drug directory could possibly be safe in short-term treatment, but wait, how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and lots of chemicals react to make a different chemical, which has an effect that could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from each other, have certain effects on one or higher body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on due to the metabolism. This makes more the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually produce the same influence on exactly the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the two drugs are more intense.
Tolerability: A medication could possibly be effective but not tolerable by all patients. Example: Allergies to a particular drugs in a few people. Short-term and long-term tolerability have to be considered. Efficacy: A medication just isn’t equally efficient at all patients. As an example, some patients with depression or anxiety attacks experience relief from escitalopram, but there are numerous that don’t, who therefore have to be prescribed another anti-depressant. The interest rate of oncoming of therapeutic action is a the answer to be looked at too.
Cost: Cost does not necessarily mean the price tag on buying a certain medicine alone. It should also cover the price tag on treatments for a complication that could arise while using another drug. Example: In a one who insists on taking alcohol and yet has to be treated for depression is generally administered an SSRI drug because they drugs don’t potentiate the results of alcohol, whereas another gang of anti-depressants (for example tricyclics) can cause a new condition in such patients, which will have to have a different and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram rather than a cheaper tricyclic in this patients.
Simplicity of treatment: The easiest mode of administration is preferred. If you have a selection between a shot and oral administration, the second is preferred in the event the efficacy of the two modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are key point to determine simple treatment.
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