Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors depending on each SARM’s chemical structure. Therefore, SARMs cause anabolic cellular activity while avoiding most of the unwanted side effects of available today steroid drugs. SARMs have already been studied within the treatment of breast cancer and cachexia and also have recently been used as performance-enhancing agents. Here, we evaluate and summarize the existing literature on SARMs.
Aim
To give the backdrop, mechanisms, current and potential clinical applications, in addition to risks and benefits of SARMs.
Methods
A literature review was performed in MEDLINE while using terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancers, benign prostatic hyperplasia, libido, and lean muscle mass. Both investigation and clinical studies were included.
Main Outcome Measure
To finish an assessment of peer-reviewed literature.
Results
However, there are presently no U.S. Drug and food Agency-approved indications for SARMs, investigators are checking out the potential purposes of these compounds. Preliminary research has dedicated to the pharmacokinetics and pharmacodynamics of those agents, demonstrating good availability having a paucity of drug interactions. Early clinical tests have demonstrated potential uses for SARMs inside the treatment of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancer, with positive results.
Conclusion
SARMs have some of possible clinical applications, with promise for the safe used in the treatment of cachexia, BPH, hypogonadism, breast cancers, and cancer of prostate.
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