Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors according to each SARM’s chemical structure. Because of this, SARMs cause anabolic cellular activity while avoiding a lot of the unwanted side effects of now available anabolic steroids. SARMs have already been studied within the treatment of cancer of the breast and cachexia and have already been used as performance-enhancing agents. Here, we evaluate and summarize the existing literature on SARMs.
Aim
To provide the setting, mechanisms, current and potential clinical applications, as well as risks and advantages of SARMs.
Methods
A literature review was performed in MEDLINE while using terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancers, benign prostatic hyperplasia, libido, and lean muscle mass. Both basic research and clinical tests were included.
Main Outcome Measure
To complete an assessment of peer-reviewed literature.
Results
Though there are presently no U.S. Food and Drug Agency-approved indications for SARMs, investigators are checking out the potential purposes of these compounds. Preliminary research has devoted to the pharmacokinetics and pharmacodynamics of such agents, demonstrating good availability using a paucity of drug interactions. Early clinical tests have demonstrated potential ways to use SARMs inside the treating cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancers, with good results.
Conclusion
SARMs have a lot of possible clinical applications, with promise for that safe use within the treating cachexia, BPH, hypogonadism, cancers of the breast, and prostate cancer.
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