SINCE Wwii, medical science has progressed to a stage where competitive medications are available to treat the same ailment in various people. This is not almost brands (the industry trade issue) but generic drugs (the industry scientific issue). Within this report, we shall look at the various factors that decide the selection of a selected drug.
Safety: The next sub-criteria have to be considered beneath the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective is really a particular drug even if it has certain side-effects providing the acuteness of the condition is lowered? Example: narcotic pain-killers work well in healing pain but come with the possible side-effect of addiction.
* Long-term safety: medicine could possibly be safe in short-term treatment, so how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and many chemicals answer make a different chemical, that have an effect that could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of one another, have certain effects on a single or even more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends upon for its metabolism. This will cause more the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually make the same relation to the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the two medicine is more serious.
Tolerability: A drug could possibly be effective however, not tolerable by all patients. Example: Allergies to specific drugs in most people. Short-term and long-term tolerability have to be taken into consideration. Efficacy: A drug just isn’t equally effective in all patients. As an example, some patients with depression or anxiety disorders experience rest from escitalopram, but there are several that don’t, who therefore have to be prescribed some other anti-depressant. The rate of onset of therapeutic action is a the answer to be regarded too.
Cost: Cost does not always mean the price of buying some medicine alone. It will also cover the price of treating a complication that could arise by using some other drug. Example: Inside a person who insists on taking alcohol and yet must be treated for depression is often administered an SSRI drug as these drugs don’t potentiate the effects of alcohol, whereas another gang of anti-depressants (including tricyclics) might cause a brand new symptom in such patients, which may require a various and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram rather than cheaper tricyclic in such patients.
Simple treatment: The simplest mode of administration is preferred. If you find an option between a shot and oral administration, rogues is preferred in the event the efficacy of the two modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are key point to determine simple treatment.
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