SINCE Wwii, medical science has progressed into a stage where competitive medications are available to treat the same ailment in numerous people. This isn’t almost brands (the trade issue) but generic drugs (the scientific issue). In this report, we shall go through the various factors that decide selecting a specific drug.
Safety: The next sub-criteria have to be considered beneath the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is really a particular drug even though it’s certain side-effects so long as the acuteness of the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but include the opportunity side-effect of addiction.
* Long-term safety: drug directory could be safe in short-term treatment, but wait, how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and several chemicals answer develop a different chemical, that have an effect which could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of one another, have certain effects one or higher body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends on because of its metabolism. This makes more the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually create the same influence on the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the prescription medication is more serious.
Tolerability: A medication could be effective and not tolerable by all patients. Example: Allergies to particular drugs in most people. Short-term and long-term tolerability have to be looked at. Efficacy: A medication isn’t equally efficient at all patients. For instance, some patients with depression or anxiety disorders experience reduced escitalopram, but there are many that do not, who therefore have to be prescribed some other anti-depressant. The rate of start of therapeutic action is a vital key to be regarded as too.
Cost: Cost does not always mean the cost of buying a particular medicine alone. It must also cover the cost of management of a complication which could arise by using some other drug. Example: Within a individual who insists on taking alcohol yet must be treated for depression is normally administered an SSRI drug because these drugs don’t potentiate the effects of alcohol, whereas another gang of anti-depressants (including tricyclics) can cause a new overuse injury in such patients, which could require a different and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram as opposed to a cheaper tricyclic such patients.
Simple treatment: The best mode of administration is preferred. If you have an alternative between an injection and oral administration, rogues is preferred when the efficacy of the modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to choose simplicity of treatment.
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