SINCE World War II, medical science has progressed with a stage where competitive medications are around for treat the identical ailment in numerous people. It’s not just about brands (that is a trade issue) but generic drugs (that is a scientific issue). Within this report, we shall consider the various factors that decide picking a a selected drug.
Safety: The following sub-criteria has to be considered under the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is often a particular drug regardless of whether it has certain side-effects as long as the acuteness from the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but come with the possible side-effect of addiction.
* Long-term safety: medicationdirectory.com could be safe in short-term treatment, but exactly how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and a lot of chemicals reply to produce a different chemical, that have an effect which could harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of one another, have certain effects using one or higher body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is dependent upon because of its metabolism. This makes an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually generate the same effect on the identical organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the medicines are more serious.
Tolerability: A medication could be effective however, not tolerable by all patients. Example: Allergies to certain drugs in most people. Short-term and long-term tolerability have to be taken into consideration. Efficacy: A medication is just not equally good at all patients. As an example, some patients with depression or panic attacks experience respite from escitalopram, but there are lots of that don’t, who therefore have to be prescribed a different anti-depressant. The pace of start of therapeutic action is a vital step to be regarded as too.
Cost: Cost does not mean the price of buying a certain medicine alone. It will also cover the price of management of a complication which could arise from utilizing a different drug. Example: In the individual that insists on taking alcohol yet should be treated for depression is generally administered an SSRI drug because these drugs don’t potentiate the consequences of alcohol, whereas another number of anti-depressants (like tricyclics) can cause a new symptom in such patients, which could require a different and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram instead of a cheaper tricyclic in this patients.
Simplicity of treatment: Most effective mode of administration is preferred. When there is a selection between a shot and oral administration, aforementioned is preferred when the efficacy of the modes can be compared. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to choose simple treatment.
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